Recent advancements in Alzheimer’s disease diagnosis are shifting from traditional cognitive assessments to the potential use of ultra-sensitive blood-based biomarkers. This evolution is important, as current diagnostic methods, like brain imaging and cerebrospinal fluid assays, are often expensive, invasive, and not widely accessible. With an estimated 7 million people living with Alzheimer’s in the U.S., early diagnosis is crucial for effective disease management and treatment application, especially with new disease-modifying therapies gaining FDA approval. While blood-based biomarkers offer a promising, cost-effective alternative, there are still significant challenges to overcome, including the need for accurate standardization and validation before these tests can be integrated into routine clinical practice. Ongoing studies are addressing these challenges and suggest that blood tests could soon play a vital role in the early identification and monitoring of Alzheimer’s disease, potentially improving patient outcomes and facilitating clinical trial recruitment.