Tuesday, April 15, 2025

Scientists Develop Light-Activated ‘Smart’ Bomb for Targeted Destruction of Breast Cancer Cells

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In a significant advancement for cancer treatment, researchers at Michigan State University and the University of California, Riverside have developed a new type of “smart” chemical for photodynamic therapy (PDT) that effectively targets aggressive breast cancer cells while minimizing harm to healthy tissue. This innovative treatment utilizes cyanine-carborane salts that, when activated by near-infrared light, generate reactive oxygen species to destroy cancer cells without lingering toxicity or side effects experienced with traditional PDT. The compounds preferentially accumulate in cancerous tissue and efficiently hit metastasizing cells, addressing long-standing limitations of existing PDT drugs. With promising results from lab tests on breast cancer models, the researchers aim to expand the treatment’s applications and enhance its safety for patients with limited options. Their findings represent a potential breakthrough in developing targeted therapies for various cancers.

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