The Potential of a Single Nitrogen Atom to Revolutionize Drug Discovery

Researchers at the University of Oklahoma have made a significant advancement in drug research by introducing a new method for adding a single nitrogen atom to molecules, a technique published in the journal Science. Led by associate professor Indrajeet Sharma, the team utilized a short-lived chemical known as sulfenylnitrene, enabling them to insert nitrogen into bioactive compounds during late-stage drug development. This innovative approach, termed skeletal editing, enhances drug diversity and maintains existing functionalities, which is crucial since a large percentage of FDA-approved drugs contain nitrogen. The cost-effective process not only simplifies drug synthesis but also has the potential to lower healthcare expenses, especially for underserved populations. This research has already attracted international attention from pharmaceutical companies eager to explore its implications for treating diseases such as cancer and neurological disorders.

The Potential of a Single Nitrogen Atom to Revolutionize Drug Discovery

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